GHRH/GHS-R Dual Secretagogue Blend
CJC-1295 (No DAC) + Ipamorelin
This research blend combines CJC-1295 without DAC (Modified GRF 1-29), a stabilized GHRH analog, with Ipamorelin, a selective GHS-R agonist. The two peptides act on distinct receptor pathways — GHRH receptors and ghrelin/GHS-R receptors respectively — producing synergistic, amplified pulsatile GH release in preclinical models. The combination is widely studied in GH axis research for its ability to maximize GH secretion while preserving physiological pulsatility and minimizing off-target effects on cortisol and prolactin.
Research Benefits
Key Research Applications
Documented areas of investigation based on peer-reviewed preclinical and clinical literature. For research reference only.
GH Axis Stimulation
Promotes natural, pulsatile growth hormone release from the anterior pituitary.
IGF-1 Elevation
Supports insulin-like growth factor-1 production for downstream anabolic signaling.
Body Composition
Studied for effects on lean mass, adipose tissue, and metabolic rate in research models.
Bone Density
Investigated for bone mineral density support in GH-deficient preclinical models.
Literature
Research Highlights
Synergistic GH release via simultaneous GHRH receptor and GHS-R activation in rodent models
Ipamorelin selectivity preserves cortisol and prolactin baseline in combination studies
Amplified IGF-1 elevation compared to either peptide administered alone in preclinical models
Physiological pulsatile GH secretion pattern maintained with dual-pathway stimulation
Specifications
Technical Data
Molecular Weight
Variable (dual-peptide blend)
Sequence / Structure
CJC-1295 (No DAC): Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH₂ | Ipamorelin: Aib-His-D-2-Nal-D-Phe-Lys-NH₂
Storage Conditions
Lyophilized: −20°C, stable 24 months. Reconstituted: 4°C, use within 28 days.
Solubility
Soluble in bacteriostatic water at ≥1 mg/mL
HPLC Purity
Verified — Batch VRC-CJI-2407
Testing Lab
Intertek Pharmaceutical Services · Jul 2026
Research Areas
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For Research Purposes Only. CJC-1295 (No DAC) + Ipamorelin is sold exclusively for in vitro laboratory research. Not for human consumption, diagnostic, therapeutic, or veterinary use. Research highlights are summaries of published preclinical and clinical studies and do not constitute medical advice or claims of efficacy. See our Research Use Disclaimer.