Epitalon / Epithalamin Tetrapeptide
Epithalon
Epithalon (Ala-Glu-Asp-Gly) is a synthetic tetrapeptide analog of epithalamin, a natural polypeptide extracted from the pineal gland. Preclinical research has investigated its role in activating telomerase, elongating telomeres in somatic cells, regulating melatonin production, and modulating neuroendocrine function. It is used as a research tool in aging biology, longevity research, and circadian rhythm studies.
Research Benefits
Key Research Applications
Documented areas of investigation based on peer-reviewed preclinical and clinical literature. For research reference only.
Telomere Biology
Studied for telomerase activation and telomere length maintenance in aging research.
Cellular Energy
Supports mitochondrial function and NAD+ dependent metabolic pathways.
DNA Repair
Investigated for PARP-mediated DNA damage repair and genomic stability.
Oxidative Stress
Modulates antioxidant defense systems and reactive oxygen species in aging models.
Literature
Research Highlights
Telomerase activation and telomere elongation in human somatic cell cultures (Khavinson et al.)
Extended lifespan in Drosophila melanogaster models with epithalon treatment
Melatonin synthesis regulation via pineal gland modulation in rodent studies
Reduced oxidative stress markers and improved antioxidant enzyme activity in aging models
Specifications
Technical Data
Molecular Weight
390.35 g/mol
Sequence / Structure
Ala-Glu-Asp-Gly
Storage Conditions
Lyophilized: −20°C, stable 24 months. Reconstituted: 4°C, use within 28 days.
Solubility
Soluble in water at ≥5 mg/mL
HPLC Purity
Verified — Batch VRC-EPI-2406
Testing Lab
Intertek Pharmaceutical Services · Jun 2026
Research Areas
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For Research Purposes Only. Epithalon is sold exclusively for in vitro laboratory research. Not for human consumption, diagnostic, therapeutic, or veterinary use. Research highlights are summaries of published preclinical and clinical studies and do not constitute medical advice or claims of efficacy. See our Research Use Disclaimer.