Nicotinamide Adenine Dinucleotide
NAD+
Nicotinamide adenine dinucleotide (NAD+) is a critical coenzyme found in all living cells, central to redox reactions in cellular energy metabolism. Research has extensively studied its role in mitochondrial function, DNA damage repair via PARP enzymes, sirtuin (SIRT1–7) activation, and circadian rhythm regulation. NAD+ levels decline with age, making it a key research tool in longevity, aging biology, and metabolic disease studies.
Research Benefits
Key Research Applications
Documented areas of investigation based on peer-reviewed preclinical and clinical literature. For research reference only.
Telomere Biology
Studied for telomerase activation and telomere length maintenance in aging research.
Cellular Energy
Supports mitochondrial function and NAD+ dependent metabolic pathways.
DNA Repair
Investigated for PARP-mediated DNA damage repair and genomic stability.
Oxidative Stress
Modulates antioxidant defense systems and reactive oxygen species in aging models.
Literature
Research Highlights
SIRT1 activation linked to improved mitochondrial biogenesis in aging models
NAD+ repletion restored muscle function in aged rodent models (Gomes et al., 2013)
PARP-mediated DNA repair enhancement observed in genotoxic stress studies
Circadian clock regulation via NAMPT-mediated NAD+ biosynthesis pathway
Specifications
Technical Data
Molecular Weight
663.43 g/mol
Sequence / Structure
Adenosine 5′-diphosphoribose nicotinamide (coenzyme)
Storage Conditions
Lyophilized: −20°C, stable 24 months. Protect from light. Reconstituted: 4°C, use within 7 days.
Solubility
Soluble in water at ≥10 mg/mL
HPLC Purity
Verified — Batch VRC-NAD-2406
Testing Lab
Intertek Pharmaceutical Services · Jun 2026
Research Areas
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For Research Purposes Only. NAD+ is sold exclusively for in vitro laboratory research. Not for human consumption, diagnostic, therapeutic, or veterinary use. Research highlights are summaries of published preclinical and clinical studies and do not constitute medical advice or claims of efficacy. See our Research Use Disclaimer.