ACTH(4-7) Pro-Gly-Pro Analog
Semax
Semax (Met-Glu-His-Phe-Pro-Gly-Pro) is a synthetic heptapeptide analog of the ACTH(4-7) fragment with a Pro-Gly-Pro C-terminal extension that confers metabolic stability. Developed in Russia and studied extensively for neuroprotective properties, BDNF and NGF upregulation, cognitive enhancement, and ischemic stroke recovery. It is used as a research tool in neuroscience, neuroprotection, and cognitive function studies.
Research Benefits
Key Research Applications
Documented areas of investigation based on peer-reviewed preclinical and clinical literature. For research reference only.
Neuroprotection
Studied for protective effects against neuronal damage and ischemic injury in preclinical models.
BDNF Upregulation
Promotes brain-derived neurotrophic factor expression supporting neuronal health.
Cognitive Function
Investigated for effects on learning, memory, and cognitive performance in research models.
Neurotransmitter Modulation
Studied for effects on serotonin, dopamine, and GABAergic signaling pathways.
Literature
Research Highlights
BDNF and NGF upregulation in hippocampal neurons observed in rodent studies
Neuroprotective effects in focal cerebral ischemia models with reduced infarct volume
Cognitive enhancement in spatial learning and memory tasks in rodent behavioral models
Approved in Russia for ischemic stroke treatment — used as reference in neuroprotection research
Specifications
Technical Data
Molecular Weight
813.94 g/mol
Sequence / Structure
Met-Glu-His-Phe-Pro-Gly-Pro
Storage Conditions
Lyophilized: −20°C, stable 24 months. Reconstituted: 4°C, use within 28 days.
Solubility
Soluble in water at ≥1 mg/mL
HPLC Purity
Verified — Batch VRC-SMX-2406
Testing Lab
SGS Life Sciences · Jun 2026
Research Areas
Ready to Order Semax?
Semax is currently in stock. View pricing, sizes, and the full Certificate of Analysis on the product page.
For Research Purposes Only. Semax is sold exclusively for in vitro laboratory research. Not for human consumption, diagnostic, therapeutic, or veterinary use. Research highlights are summaries of published preclinical and clinical studies and do not constitute medical advice or claims of efficacy. See our Research Use Disclaimer.