Thymosin Beta-4 Fragment
TB-500
TB-500 is a synthetic peptide fragment of the naturally occurring protein Thymosin Beta-4 (Tβ4). The active region of Tβ4 responsible for actin binding and cellular migration is replicated in TB-500. Preclinical studies have explored its role in promoting angiogenesis, reducing inflammation, and accelerating wound closure. It has been studied in models of cardiac repair, corneal healing, and dermal wound healing.
Research Benefits
Key Research Applications
Documented areas of investigation based on peer-reviewed preclinical and clinical literature. For research reference only.
Accelerated Healing
Supports rapid tissue repair and wound closure mechanisms in preclinical models.
Cellular Regeneration
Promotes cellular migration and proliferation essential for tissue regeneration.
Anti-Inflammatory
Modulates inflammatory pathways to support the healing environment.
Structural Integrity
Supports collagen synthesis and extracellular matrix remodeling.
Literature
Research Highlights
Promoted angiogenesis and endothelial cell migration in in vitro assays
Reduced infarct size in rodent myocardial infarction models
Accelerated corneal wound healing in rabbit models
Anti-inflammatory effects observed via NF-κB pathway modulation
Specifications
Technical Data
Molecular Weight
4963.44 g/mol
Sequence / Structure
Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser
Storage Conditions
Lyophilized: −20°C, stable 24 months. Reconstituted: 4°C, use within 28 days.
Solubility
Soluble in water at ≥1 mg/mL
HPLC Purity
Verified — Batch VRC-TB5-2406
Testing Lab
Eurofins Scientific · Jun 2026
Research Areas
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For Research Purposes Only. TB-500 is sold exclusively for in vitro laboratory research. Not for human consumption, diagnostic, therapeutic, or veterinary use. Research highlights are summaries of published preclinical and clinical studies and do not constitute medical advice or claims of efficacy. See our Research Use Disclaimer.