GIP/GLP-1 Dual Receptor Agonist
Tirzepatide
Tirzepatide is a novel dual agonist targeting both the glucose-dependent insulinotropic polypeptide (GIP) receptor and the glucagon-like peptide-1 (GLP-1) receptor. This dual mechanism has demonstrated enhanced glycemic control and weight reduction compared to single-receptor agonists in preclinical and clinical research. It is used as a research tool in type 2 diabetes, obesity, and metabolic syndrome models.
Research Benefits
Key Research Applications
Documented areas of investigation based on peer-reviewed preclinical and clinical literature. For research reference only.
Glucose Regulation
Modulates glucose-dependent insulin secretion and glycemic control pathways.
Energy Expenditure
Studied for effects on metabolic rate and energy homeostasis in preclinical models.
Body Weight Modulation
Investigated for appetite signaling and adipose tissue regulation mechanisms.
Cardiometabolic Health
Research has explored effects on lipid profiles, blood pressure, and cardiovascular markers.
Literature
Research Highlights
Superior HbA1c reduction vs. semaglutide in SURPASS clinical trial program
Up to 22.5% body weight reduction observed in SURMOUNT-1 Phase 3 trial
Dual receptor engagement enhances insulin secretion and reduces glucagon
Improved lipid profiles and blood pressure observed in metabolic research models
Specifications
Technical Data
Molecular Weight
4813.48 g/mol
Sequence / Structure
Tyr-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Ile-Ala-Met-Asp-Lys-Ile-His-Gln-Gln-Asp-Phe-Val-Asn-Trp-Leu-Leu-Ala-Gln-Gly-Lys(C20 diacid)-Gly-NH₂
Storage Conditions
Lyophilized: −20°C, stable 24 months. Reconstituted: 4°C, use within 28 days.
Solubility
Soluble in 10mM PBS pH 7.4 at ≥1 mg/mL
HPLC Purity
Verified — Batch VRC-TIR-2406
Testing Lab
Intertek Pharmaceutical Services · Jun 2026
Research Areas
Ready to Order Tirzepatide?
Tirzepatide is currently in stock. View pricing, sizes, and the full Certificate of Analysis on the product page.
For Research Purposes Only. Tirzepatide is sold exclusively for in vitro laboratory research. Not for human consumption, diagnostic, therapeutic, or veterinary use. Research highlights are summaries of published preclinical and clinical studies and do not constitute medical advice or claims of efficacy. See our Research Use Disclaimer.