Lysine-Proline-Valine Tripeptide
KPV
C-terminal α-MSH tripeptide studied for potent anti-inflammatory effects, gut barrier protection, and melanocortin receptor-independent signaling in preclinical models.
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Tested by: SGS Life Sciences · Batch: VRC-KPV-2407 · Jul 2026
About KPV
KPV (Lys-Pro-Val) is the C-terminal tripeptide of α-melanocyte-stimulating hormone (α-MSH), representing the minimal active sequence responsible for its anti-inflammatory properties. Unlike full-length α-MSH, KPV exerts its effects through both melanocortin receptor-dependent and independent pathways. Preclinical research has studied its potent anti-inflammatory activity in models of inflammatory bowel disease, colitis, skin inflammation, and wound healing. Its small size enables efficient cellular uptake and gut epithelial penetration, making it a valuable research tool in mucosal immunity and barrier function studies.
Research Areas
Technical Specifications
Molecular Weight
341.41 g/mol
Amino Acid Sequence
Lys-Pro-Val
Storage
Lyophilized: −20°C, stable 24 months. Reconstituted: 4°C, use within 28 days.
Solubility
Soluble in water at ≥5 mg/mL
For Research Purposes Only. KPV is sold exclusively for in vitro laboratory research. Not for human consumption, diagnostic, therapeutic, or veterinary use. See our Research Use Disclaimer.