NNMT Inhibitor / Methylquinolinium Analog
5-Amino-1MQ
5-Amino-1MQ (5-amino-1-methylquinolinium) is a cell-permeable small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that consumes SAM (S-adenosylmethionine) and produces 1-methylnicotinamide. By inhibiting NNMT, 5-Amino-1MQ increases intracellular SAM and NAD+ precursor availability, shifting cellular metabolism toward reduced adipogenesis and increased energy expenditure. Preclinical research has studied its effects on adipocyte differentiation, fat mass reduction, and metabolic reprogramming in diet-induced obesity models. It is a novel research tool in metabolic disease, epigenetics, and NAD+ biology.
Research Benefits
Key Research Applications
Documented areas of investigation based on peer-reviewed preclinical and clinical literature. For research reference only.
Glucose Regulation
Modulates glucose-dependent insulin secretion and glycemic control pathways.
Energy Expenditure
Studied for effects on metabolic rate and energy homeostasis in preclinical models.
Body Weight Modulation
Investigated for appetite signaling and adipose tissue regulation mechanisms.
Cardiometabolic Health
Research has explored effects on lipid profiles, blood pressure, and cardiovascular markers.
Literature
Research Highlights
NNMT inhibition increases SAM availability and suppresses adipocyte differentiation in vitro
Significant fat mass reduction in diet-induced obese mouse models (Kannt et al., 2015)
NAD+ precursor pool expansion via reduced SAM consumption in metabolic reprogramming studies
Epigenetic effects via altered methylation status studied in adipose tissue models
Specifications
Technical Data
Molecular Weight
174.20 g/mol
Sequence / Structure
Small molecule — 5-amino-1-methylquinolinium (non-peptide)
Storage Conditions
Lyophilized: −20°C, stable 24 months. Protect from light. Reconstituted: 4°C, use within 28 days.
Solubility
Soluble in DMSO at ≥50 mg/mL; soluble in water at ≥5 mg/mL
HPLC Purity
Verified — Batch VRC-5AM-2407
Testing Lab
Eurofins Scientific · Jul 2026
Research Areas
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For Research Purposes Only. 5-Amino-1MQ is sold exclusively for in vitro laboratory research. Not for human consumption, diagnostic, therapeutic, or veterinary use. Research highlights are summaries of published preclinical and clinical studies and do not constitute medical advice or claims of efficacy. See our Research Use Disclaimer.