NNMT Inhibitor / Methylquinolinium Analog
5-Amino-1MQ
Small-molecule NNMT inhibitor studied for adipogenesis suppression, NAD+ precursor availability, and metabolic reprogramming in preclinical obesity and metabolic research.
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Tested by: Eurofins Scientific · Batch: VRC-5AM-2407 · Jul 2026
About 5-Amino-1MQ
5-Amino-1MQ (5-amino-1-methylquinolinium) is a cell-permeable small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that consumes SAM (S-adenosylmethionine) and produces 1-methylnicotinamide. By inhibiting NNMT, 5-Amino-1MQ increases intracellular SAM and NAD+ precursor availability, shifting cellular metabolism toward reduced adipogenesis and increased energy expenditure. Preclinical research has studied its effects on adipocyte differentiation, fat mass reduction, and metabolic reprogramming in diet-induced obesity models. It is a novel research tool in metabolic disease, epigenetics, and NAD+ biology.
Research Areas
Technical Specifications
Molecular Weight
174.20 g/mol
Amino Acid Sequence
Small molecule — 5-amino-1-methylquinolinium (non-peptide)
Storage
Lyophilized: −20°C, stable 24 months. Protect from light. Reconstituted: 4°C, use within 28 days.
Solubility
Soluble in DMSO at ≥50 mg/mL; soluble in water at ≥5 mg/mL
For Research Purposes Only. 5-Amino-1MQ is sold exclusively for in vitro laboratory research. Not for human consumption, diagnostic, therapeutic, or veterinary use. See our Research Use Disclaimer.