Cibinetide / Non-Hematopoietic EPO Analog
ARA-290
ARA-290 (cibinetide) is a synthetic 11-amino acid peptide derived from the helix B surface of erythropoietin (EPO), engineered to activate the innate repair receptor (IRR) — a heterodimer of the EPO receptor and the common beta chain — without triggering erythropoiesis. Preclinical research has studied its neuroprotective, anti-inflammatory, and tissue repair properties in models of neuropathic pain, diabetic neuropathy, sarcoidosis, and ischemic injury. It is a valuable research tool for dissecting EPO's cytoprotective functions from its hematopoietic effects.
Research Benefits
Key Research Applications
Documented areas of investigation based on peer-reviewed preclinical and clinical literature. For research reference only.
Neuroprotection
Studied for protective effects against neuronal damage and ischemic injury in preclinical models.
BDNF Upregulation
Promotes brain-derived neurotrophic factor expression supporting neuronal health.
Cognitive Function
Investigated for effects on learning, memory, and cognitive performance in research models.
Neurotransmitter Modulation
Studied for effects on serotonin, dopamine, and GABAergic signaling pathways.
Literature
Research Highlights
Innate repair receptor (IRR) activation without erythropoietic side effects (Brines et al., 2008)
Neuropathic pain reduction in small fiber neuropathy clinical studies (Culver et al., 2017)
Anti-inflammatory effects via NF-κB suppression and IL-10 upregulation in macrophage models
Tissue protection in ischemia-reperfusion injury models across cardiac and renal systems
Specifications
Technical Data
Molecular Weight
1338.5 g/mol
Sequence / Structure
Gln-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser
Storage Conditions
Lyophilized: −20°C, stable 24 months. Reconstituted: 4°C, use within 28 days.
Solubility
Soluble in water at ≥1 mg/mL
HPLC Purity
Verified — Batch VRC-ARA-2407
Testing Lab
Eurofins Scientific · Jul 2026
Research Areas
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For Research Purposes Only. ARA-290 is sold exclusively for in vitro laboratory research. Not for human consumption, diagnostic, therapeutic, or veterinary use. Research highlights are summaries of published preclinical and clinical studies and do not constitute medical advice or claims of efficacy. See our Research Use Disclaimer.