Mitochondrial Open Reading Frame Peptide
MOTS-c
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA type-c) is a mitochondria-derived peptide encoded within the mitochondrial genome. Preclinical research has investigated its role as a metabolic regulator, with studies showing effects on insulin sensitivity, glucose uptake, AMPK activation, and exercise-like metabolic responses. It is studied as a potential tool compound in metabolic disease, aging, and exercise physiology research.
Research Benefits
Key Research Applications
Documented areas of investigation based on peer-reviewed preclinical and clinical literature. For research reference only.
Glucose Regulation
Modulates glucose-dependent insulin secretion and glycemic control pathways.
Energy Expenditure
Studied for effects on metabolic rate and energy homeostasis in preclinical models.
Body Weight Modulation
Investigated for appetite signaling and adipose tissue regulation mechanisms.
Cardiometabolic Health
Research has explored effects on lipid profiles, blood pressure, and cardiovascular markers.
Literature
Research Highlights
AMPK activation and improved insulin sensitivity in high-fat diet rodent models (Lee et al., 2015)
Exercise mimetic effects on skeletal muscle glucose uptake observed in vitro
Age-related decline in circulating MOTS-c levels linked to metabolic dysfunction
Protective effects against diet-induced obesity in preclinical studies
Specifications
Technical Data
Molecular Weight
2174.5 g/mol
Sequence / Structure
Tyr-Trp-Leu-Thr-Lys-Leu-Ile-Thr-Tyr-Leu-Lys-Lys-Gly-Glu-Ile-Lys-Glu-Leu-Leu-Glu-Lys-Leu-Glu-Glu-Leu-Lys-Lys-Leu-Lys-Glu-Glu-Leu-Glu-Lys
Storage Conditions
Lyophilized: −20°C, stable 24 months. Reconstituted: 4°C, use within 28 days.
Solubility
Soluble in water at ≥1 mg/mL
HPLC Purity
Verified — Batch VRC-MOT-2406
Testing Lab
SGS Life Sciences · Jun 2026
Research Areas
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For Research Purposes Only. MOTS-c is sold exclusively for in vitro laboratory research. Not for human consumption, diagnostic, therapeutic, or veterinary use. Research highlights are summaries of published preclinical and clinical studies and do not constitute medical advice or claims of efficacy. See our Research Use Disclaimer.