Bremelanotide
PT-141
PT-141 (Bremelanotide) is a cyclic heptapeptide melanocortin receptor agonist derived from the tanning peptide Melanotan II. It acts centrally via MC3R and MC4R receptors in the hypothalamus, distinguishing it from PDE5 inhibitors that act peripherally. Preclinical and clinical research has studied its role in sexual arousal pathways, CNS-mediated desire signaling, and its potential in hypoactive sexual desire disorder (HSDD) models.
Research Benefits
Key Research Applications
Documented areas of investigation based on peer-reviewed preclinical and clinical literature. For research reference only.
Melanocortin Activation
Acts via central melanocortin receptor pathways distinct from peripheral mechanisms.
CNS-Mediated Pathways
Studied for hypothalamic signaling effects in preclinical arousal and desire research.
Receptor Selectivity
Characterized binding profiles across melanocortin receptor subtypes (MC1R–MC5R).
Clinical Research Base
Supported by preclinical and clinical research with FDA-approved analogs.
Literature
Research Highlights
CNS-mediated arousal via MC3R/MC4R activation distinct from PDE5 inhibitor mechanisms
Significant improvement in FSFI scores in HSDD clinical trials
Dose-dependent erectile response in rat models independent of peripheral vasodilation
FDA-approved analog (Vyleesi) for HSDD in premenopausal women (2019)
Specifications
Technical Data
Molecular Weight
1025.18 g/mol
Sequence / Structure
Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH
Storage Conditions
Lyophilized: −20°C, stable 24 months. Reconstituted: 4°C, use within 28 days.
Solubility
Soluble in water at ≥1 mg/mL
HPLC Purity
Verified — Batch VRC-PT1-2406
Testing Lab
SGS Life Sciences · Jun 2026
Research Areas
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For Research Purposes Only. PT-141 is sold exclusively for in vitro laboratory research. Not for human consumption, diagnostic, therapeutic, or veterinary use. Research highlights are summaries of published preclinical and clinical studies and do not constitute medical advice or claims of efficacy. See our Research Use Disclaimer.