GLP-1 Receptor Agonist
Semaglutide
Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist with 94% sequence homology to human GLP-1. It features a C18 fatty diacid chain enabling albumin binding and extended half-life. Preclinical and clinical research has extensively studied its role in glucose-dependent insulin secretion, appetite suppression via hypothalamic pathways, gastric emptying delay, and body weight regulation. It is widely used as a research tool in metabolic disease models.
Research Benefits
Key Research Applications
Documented areas of investigation based on peer-reviewed preclinical and clinical literature. For research reference only.
Glucose Regulation
Modulates glucose-dependent insulin secretion and glycemic control pathways.
Energy Expenditure
Studied for effects on metabolic rate and energy homeostasis in preclinical models.
Body Weight Modulation
Investigated for appetite signaling and adipose tissue regulation mechanisms.
Cardiometabolic Health
Research has explored effects on lipid profiles, blood pressure, and cardiovascular markers.
Literature
Research Highlights
Dose-dependent reduction in HbA1c in T2DM rodent models
Significant body weight reduction via hypothalamic appetite suppression
Cardiovascular risk reduction observed in SUSTAIN-6 clinical trial
Neuroprotective effects studied in Alzheimer's disease preclinical models
Specifications
Technical Data
Molecular Weight
4113.58 g/mol
Sequence / Structure
His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(C18 diacid)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg
Storage Conditions
Lyophilized: −20°C, stable 24 months. Reconstituted: 4°C, use within 28 days.
Solubility
Soluble in 10mM PBS pH 7.4 at ≥1 mg/mL
HPLC Purity
Verified — Batch VRC-SEM-2406
Testing Lab
SGS Life Sciences · Jun 2026
Research Areas
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For Research Purposes Only. Semaglutide is sold exclusively for in vitro laboratory research. Not for human consumption, diagnostic, therapeutic, or veterinary use. Research highlights are summaries of published preclinical and clinical studies and do not constitute medical advice or claims of efficacy. See our Research Use Disclaimer.