GHRH(1-29) Analog
Sermorelin
Sermorelin (GHRH 1-29 NH₂) is a synthetic peptide corresponding to the first 29 amino acids of endogenous growth hormone-releasing hormone, representing the shortest fully active fragment. It stimulates the pituitary gland to produce and secrete GH in a physiological, pulsatile manner. Preclinical and clinical research has studied its role in GH deficiency models, IGF-1 elevation, and age-related GH decline. It is used as a reference GHRH agonist in growth hormone axis research.
Research Benefits
Key Research Applications
Documented areas of investigation based on peer-reviewed preclinical and clinical literature. For research reference only.
GH Axis Stimulation
Promotes natural, pulsatile growth hormone release from the anterior pituitary.
IGF-1 Elevation
Supports insulin-like growth factor-1 production for downstream anabolic signaling.
Body Composition
Studied for effects on lean mass, adipose tissue, and metabolic rate in research models.
Bone Density
Investigated for bone mineral density support in GH-deficient preclinical models.
Literature
Research Highlights
Shortest fully active GHRH fragment — standard reference agonist for GH axis research
Physiological pulsatile GH secretion preserved vs. continuous GH administration
IGF-1 elevation and improved body composition in GH-deficient rodent models
Age-related GH decline reversal studied in elderly subject clinical research (Walker et al.)
Specifications
Technical Data
Molecular Weight
3357.93 g/mol
Sequence / Structure
Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH₂
Storage Conditions
Lyophilized: −20°C, stable 24 months. Reconstituted: 4°C, use within 28 days.
Solubility
Soluble in sterile water at ≥1 mg/mL
HPLC Purity
Verified — Batch VRC-SRM-2406
Testing Lab
SGS Life Sciences · Jun 2026
Research Areas
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For Research Purposes Only. Sermorelin is sold exclusively for in vitro laboratory research. Not for human consumption, diagnostic, therapeutic, or veterinary use. Research highlights are summaries of published preclinical and clinical studies and do not constitute medical advice or claims of efficacy. See our Research Use Disclaimer.