Elamipretide / Szeto-Schiller Peptide
SS-31
SS-31 (elamipretide, D-Arg-2′6′-Dmt-Lys-Phe-NH₂) is a cell-permeable, mitochondria-targeted tetrapeptide from the Szeto-Schiller peptide family. It selectively concentrates in the inner mitochondrial membrane where it binds cardiolipin, stabilizing cristae architecture and protecting electron transport chain complexes. Preclinical research has studied its role in reducing mitochondrial ROS, improving ATP production, and protecting against ischemia-reperfusion injury. It is a key research tool in mitochondrial biology, aging, and cardiac research.
Research Benefits
Key Research Applications
Documented areas of investigation based on peer-reviewed preclinical and clinical literature. For research reference only.
Telomere Biology
Studied for telomerase activation and telomere length maintenance in aging research.
Cellular Energy
Supports mitochondrial function and NAD+ dependent metabolic pathways.
DNA Repair
Investigated for PARP-mediated DNA damage repair and genomic stability.
Oxidative Stress
Modulates antioxidant defense systems and reactive oxygen species in aging models.
Literature
Research Highlights
Cardiolipin binding stabilizes inner mitochondrial membrane cristae architecture in vitro
Reduced mitochondrial ROS and improved ATP synthesis in ischemia-reperfusion rodent models
Cardiac protection via electron transport chain complex I and III preservation (Szeto et al.)
Age-related mitochondrial dysfunction reversal studied in skeletal muscle aging models
Specifications
Technical Data
Molecular Weight
639.80 g/mol
Sequence / Structure
D-Arg-2′6′-Dmt-Lys-Phe-NH₂
Storage Conditions
Lyophilized: −20°C, stable 24 months. Protect from light. Reconstituted: 4°C, use within 14 days.
Solubility
Soluble in water at ≥5 mg/mL
HPLC Purity
Verified — Batch VRC-SS3-2407
Testing Lab
SGS Life Sciences · Jul 2026
Research Areas
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For Research Purposes Only. SS-31 is sold exclusively for in vitro laboratory research. Not for human consumption, diagnostic, therapeutic, or veterinary use. Research highlights are summaries of published preclinical and clinical studies and do not constitute medical advice or claims of efficacy. See our Research Use Disclaimer.