GHRH Analog (Trans-3-hexenoic acid)
Tesamorelin
Tesamorelin is a synthetic analog of growth hormone-releasing hormone (GHRH) stabilized with a trans-3-hexenoic acid modification that extends its half-life relative to native GHRH. It stimulates pulsatile GH secretion from the anterior pituitary and has been studied for its effects on IGF-1 elevation and visceral adipose tissue reduction. An FDA-approved form (Egrifta) is used for HIV-associated lipodystrophy, making it a well-characterized research tool in GH axis and metabolic studies.
Research Benefits
Key Research Applications
Documented areas of investigation based on peer-reviewed preclinical and clinical literature. For research reference only.
GH Axis Stimulation
Promotes natural, pulsatile growth hormone release from the anterior pituitary.
IGF-1 Elevation
Supports insulin-like growth factor-1 production for downstream anabolic signaling.
Body Composition
Studied for effects on lean mass, adipose tissue, and metabolic rate in research models.
Bone Density
Investigated for bone mineral density support in GH-deficient preclinical models.
Literature
Research Highlights
FDA-approved (Egrifta) for HIV-associated lipodystrophy — well-characterized GH axis tool
Significant visceral adipose tissue reduction in Phase 3 clinical trials (Falutz et al., 2010)
Sustained IGF-1 elevation without disrupting normal pulsatile GH secretion patterns
Improved lipid profiles and trunk fat reduction observed in metabolic research models
Specifications
Technical Data
Molecular Weight
5135.88 g/mol
Sequence / Structure
Trans-3-hexenoic acid-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu-NH₂
Storage Conditions
Lyophilized: −20°C, stable 24 months. Reconstituted: 4°C, use within 28 days.
Solubility
Soluble in sterile water at ≥1 mg/mL
HPLC Purity
Verified — Batch VRC-TES-2406
Testing Lab
Eurofins Scientific · Jun 2026
Research Areas
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For Research Purposes Only. Tesamorelin is sold exclusively for in vitro laboratory research. Not for human consumption, diagnostic, therapeutic, or veterinary use. Research highlights are summaries of published preclinical and clinical studies and do not constitute medical advice or claims of efficacy. See our Research Use Disclaimer.